Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability

  title={Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability},
  author={Elisa M. S. Tam and Zhen Liu and Tsz Ping Lam and Terry Ting and Gordon Cheung and Bobby Kin-Wah Ng and Simon K. M. Lee and Yong Qiu and Jack Chun-yiu Cheng},
Study Design. This was a case-control study. Objective. This study aimed to investigate the body composition and its correlation with leptin and soluble leptin receptor (sOB-R) levels in girls with adolescent idiopathic scoliosis (AIS) and compared with healthy controls. Summary of Background Data. Patients with AIS are associated with lower body weight, taller stature, lower body mass index (BMI), and deranged bone quality. Despite the widely reported lower BMI and body weight in girls with… 

Association between Bone Turnover Markers, Leptin, and Nutritional Status in Girls with Adolescent Idiopathic Scoliosis (AIS)

Bone metabolism in AIS girls seems to be altered and significantly related to the scoliotic curve severity, and leptin may be a crucial link in the cross-talk between bone turnover and body composition in this group of patients.

Body Composition in Japanese Girls with Adolescent Idiopathic Scoliosis

Patients with AIS are thinner, with lower BMI, %BF, and LMI compared with healthy girls of the same age, and factors such as higher BMI, lower muscle mass, and lower estimated bone mass were correlated with progressive scoliosis.

Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): a systematic review and meta-analysis

It was showed that serum level of leptin in AIS patients was significantly lower when compared with control subjects, while serum sOB-R and ghrelin levels were significantly higher in Ais patients.

Biological effect of dysregulated LBX1 on Adolescent Idiopathic Scoliosis through modulating muscle carbohydrate metabolism.

Nutrition and physical activity level of adolescents with idiopathic scoliosis: A narrative review.

Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review

It is demonstrated that patients with AIS are significantly more likely to have a low BMI compared to the general population, and it is advocated that closer attention be paid to AIS patients with low BMI both pre- and postsurgical correction.

The Relationship Between Body Mass Index and the Magnitude of Curve at Diagnosis of Adolescent Idiopathic Scoliosis: A Retrospective Chart Review

The relationship between BMI varied by curve location within this cohort, in which most patients presented with a BMI <85th percentile, highlight the importance of sensitive history taking and careful physical examination for early detection of scoliosis.

Leptin in adolescent idiopathic scoliosis – A meta-analysis

Bone Metabolism in AIS

Serological and cellular functional studies supported the presence of abnormal bone formation and resorption that might have contributed to the abnormal bone qualities and bone strength which could be linked to the etiopathogenesis of AIS.



Abnormal Leptin Bioavailability in Adolescent Idiopathic Scoliosis: An Important New Finding

This is the first study demonstrating the presence of abnormal leptin bioavailability in AIS girls that might play an important role in the etiopathogenesis of AIS.

Body composition in adolescent idiopathic scoliosis

The conclusion is that there is a real alteration of body composition in AIS, and the BMI, FFMi and FMi are lower than in the general population in the series under study.

Anthropometry and Body Composition Profile of Girls With Nonsurgically Treated Adolescent Idiopathic Scoliosis

The differences in some anthropometric parameters and in the somatotype suggest that the idiopathic scoliosis not only disturbs normal spine growth but also seems to have implications on the whole corporal development.

Generalized low bone mass of girls with adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period

In conclusion, AIS girls were found to have lower body weight and BMI, longer segmental lengths and generalized low bone mass and the importance of preventing generalized osteopenia in the control of AIS progression during the peripubertal period warrants further study.

Are Volumetric Bone Mineral Density and Bone Micro-Architecture Associated with Leptin and Soluble Leptin Receptor Levels in Adolescent Idiopathic Scoliosis? – A Case-Control Study

Bone quality in AIS girls was deranged as compared with controls, and the distinct differences in correlation pattern between leptin and trabecular bone parameters indicated possible abnormalities in bone metabolism and dysfunction of the leptin signaling pathway in A IS.

Leptin is inversely related to age at menarche in human females.

A critical blood leptin level is necessary to trigger reproductive ability in women, suggesting a threshold effect, and leptin is a mediator between adipose tissue and the gonads and may also mediate the effect of obesity on bone mass by influencing the periosteal envelope.

Bone mineral density in prepubertal obese and control children: relation to body weight, lean mass, and fat mass

It was observed that, in obese children, cortical and trabecular bone displayed different adaptation patterns to their higher body weight and these skeletal responses were not sufficient to compensate for the excess load on the whole body.

Regional fat distribution in adolescents with anorexia nervosa: effect of duration of malnutrition and weight recovery.

Prolonged malnutrition, but not weight recovery, is associated with an abnormal regional fat distribution pattern in moderately malnourished AN adolescents.

Association of lean tissue and fat mass with bone mineral content in children and adolescents.

The hypothesis that in children and adolescents a close association exists between LTM, a measure of skeletal muscle, and skeletal characteristics, is supported.

Skeletal and body-composition effects of anorexia nervosa.

Eleven female patients with anorexia nervosa were measured by use of dual-photon absorptiometry for bone mineral content and bone mineral density of the total skeleton and its regions, BMD of the lumbar spine and the proximal femur, and total body soft-tissue composition.