Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability

@article{Tam2016LowerMM,
  title={Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability},
  author={Elisa M. S. Tam and Zhen Liu and Tsz Ping Lam and Terry Ting and Gordon Cheung and Bobby Kin-Wah Ng and Simon K. M. Lee and Yong Qiu and Jack Chun-yiu Cheng},
  journal={SPINE},
  year={2016},
  volume={41},
  pages={940–946}
}
Study Design. This was a case-control study. Objective. This study aimed to investigate the body composition and its correlation with leptin and soluble leptin receptor (sOB-R) levels in girls with adolescent idiopathic scoliosis (AIS) and compared with healthy controls. Summary of Background Data. Patients with AIS are associated with lower body weight, taller stature, lower body mass index (BMI), and deranged bone quality. Despite the widely reported lower BMI and body weight in girls with… 

Association between Bone Turnover Markers, Leptin, and Nutritional Status in Girls with Adolescent Idiopathic Scoliosis (AIS)

Bone metabolism in AIS girls seems to be altered and significantly related to the scoliotic curve severity, and leptin may be a crucial link in the cross-talk between bone turnover and body composition in this group of patients.

Body Composition in Japanese Girls with Adolescent Idiopathic Scoliosis

Patients with AIS are thinner, with lower BMI, %BF, and LMI compared with healthy girls of the same age, and factors such as higher BMI, lower muscle mass, and lower estimated bone mass were correlated with progressive scoliosis.

Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): a systematic review and meta-analysis

It was showed that serum level of leptin in AIS patients was significantly lower when compared with control subjects, while serum sOB-R and ghrelin levels were significantly higher in Ais patients.

Biological effect of dysregulated LBX1 on Adolescent Idiopathic Scoliosis through modulating muscle carbohydrate metabolism.

Nutrition and physical activity level of adolescents with idiopathic scoliosis: A narrative review.

Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review

It is demonstrated that patients with AIS are significantly more likely to have a low BMI compared to the general population, and it is advocated that closer attention be paid to AIS patients with low BMI both pre- and postsurgical correction.

The Relationship Between Body Mass Index and the Magnitude of Curve at Diagnosis of Adolescent Idiopathic Scoliosis: A Retrospective Chart Review

The relationship between BMI varied by curve location within this cohort, in which most patients presented with a BMI <85th percentile, highlight the importance of sensitive history taking and careful physical examination for early detection of scoliosis.

Leptin in adolescent idiopathic scoliosis – A meta-analysis

Bone Metabolism in AIS

Serological and cellular functional studies supported the presence of abnormal bone formation and resorption that might have contributed to the abnormal bone qualities and bone strength which could be linked to the etiopathogenesis of AIS.

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