Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

@article{GodoyLozano2016LowerIS,
  title={Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response},
  author={Elizabeth Ernestina Godoy-Lozano and Juan T{\'e}llez-Sosa and Gilberto S{\'a}nchez-Gonz{\'a}lez and Hugo S{\'a}mano-S{\'a}nchez and Andr{\'e}s Aguilar-Salgado and Aar{\'o}n Salinas-Rodr{\'i}guez and Bernardo Cortina-Ceballos and H{\'e}ctor Vivanco-Cid and Karina G Hern{\'a}ndez-Flores and Jennifer M. Pfaff and Kristen M Kahle and Benjamin J. Doranz and Rosa Elena G{\'o}mez-Barreto and Humberto Valdovinos-Torres and Irma Elena L{\'o}pez-Mart{\'i}nez and Mario Henry Rodr{\'i}guez and Jes{\'u}s Mart{\'i}nez-Barnetche},
  journal={Genome Medicine},
  year={2016},
  volume={8},
  pages={1-19}
}
The study of human B cell response to dengue virus (DENV) infection is critical to understand serotype-specific protection and the cross-reactive sub-neutralizing response. Whereas the first is beneficial and thus represents the ultimate goal of vaccination, the latter has been implicated in the development of severe disease, which occurs in a small, albeit significant, fraction of secondary DENV infections. Both primary and secondary infections are associated with the production of poly… CONTINUE READING
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