Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

@article{GodoyLozano2016LowerIS,
  title={Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response},
  author={E. Godoy-Lozano and J. T{\'e}llez-Sosa and G. S{\'a}nchez-Gonz{\'a}lez and Hugo S{\'a}mano-S{\'a}nchez and Andr{\'e}s Aguilar-Salgado and A. Salinas-Rodr{\'i}guez and Bernardo Cortina-Ceballos and H. Vivanco-Cid and K. Hernandez-Flores and J. Pfaff and Kristen M Kahle and B. Doranz and R. E. G{\'o}mez-Barreto and H. Valdovinos-Torres and I. L{\'o}pez-Mart{\'i}nez and M. Rodr{\'i}guez and J. Martinez-Barnetche},
  journal={Genome Medicine},
  year={2016},
  volume={8}
}
  • E. Godoy-Lozano, J. Téllez-Sosa, +14 authors J. Martinez-Barnetche
  • Published 2016
  • Medicine, Biology
  • Genome Medicine
  • BackgroundThe study of human B cell response to dengue virus (DENV) infection is critical to understand serotype-specific protection and the cross-reactive sub-neutralizing response. Whereas the first is beneficial and thus represents the ultimate goal of vaccination, the latter has been implicated in the development of severe disease, which occurs in a small, albeit significant, fraction of secondary DENV infections. Both primary and secondary infections are associated with the production of… CONTINUE READING
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