Lower Apo A-I and lower HDL-C levels are associated with higher intermediate CD14++CD16+ monocyte counts that predict cardiovascular events in chronic kidney disease.

@article{Rogacev2014LowerAA,
  title={Lower Apo A-I and lower HDL-C levels are associated with higher intermediate CD14++CD16+ monocyte counts that predict cardiovascular events in chronic kidney disease.},
  author={Kyrill S. Rogacev and Adam M. Zawada and Insa E. Emrich and Sarah H Seiler and Michael B{\"o}hm and Danilo Fliser and Kevin J. Woollard and Gunnar Henrik Heine},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 9},
  pages={2120-7}
}
OBJECTIVE Patients with chronic kidney disease (CKD) display impaired cholesterol efflux capacity and elevated CD14(++)CD16(+) monocyte counts. In mice, dysfunctional cholesterol efflux causes monocytosis. It is unknown whether cholesterol efflux capacity and monocyte subsets are associated in CKD. APPROACH AND RESULTS In 438 patients with CKD, mediators of cholesterol efflux capacity (high-density lipoprotein cholesterol/apolipoprotein A-I) and monocyte subsets were analyzed as predictors of… CONTINUE READING
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