Lowdenic acid: a new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp.

@article{Angawi2003LowdenicAA,
  title={Lowdenic acid: a new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp.},
  author={Rihab F. Angawi and Dale C. Swenson and James B Gloer and Donald T. Wicklow},
  journal={Journal of natural products},
  year={2003},
  volume={66 9},
  pages={1259-62}
}
Lowdenic acid (1), a new antifungal metabolite with an unusual structure and a mixed biogenetic origin, has been obtained from nonsporulating cultures of a previously undescribed Verticillium sp. (MYC-406 = NRRL 29280) that was isolated as a colonist of polypore basidiomata. The gross structure of 1 was proposed by analysis of NMR data and confirmed by X-ray diffraction analysis, which enabled assignment of relative stereochemistry. Compound 1 occurs as an equilibrium E/Z mixture. The known… CONTINUE READING