Low volume ventilation with permissive hypercapnia in the Adult Respiratory Distress Syndrome.

@article{Hickling1992LowVV,
  title={Low volume ventilation with permissive hypercapnia in the Adult Respiratory Distress Syndrome.},
  author={Keith G. Hickling},
  journal={Clinical intensive care : international journal of critical & coronary care medicine},
  year={1992},
  volume={3 2},
  pages={67-78}
}
  • Keith G. Hickling
  • Published 1992 in
    Clinical intensive care : international journal…
Many animal studies have demonstrated that mechanical ventilation with high peak inspiratory pressures (PIP) can result in a form of acute lung injury closely resembling ARDS, ie characterised by hyaline membranes, granulocyte infiltration, increased pulmonary and systemic vascular permeability, and eventually proliferation of fibroblasts and type II pneumocytes. These studies have led to a concern that, in some patients, orthodox ventilatory management in severe ARDS may result in additional… CONTINUE READING