Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits.

@article{Dangelo2002LowvolumeVC,
  title={Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits.},
  author={Emanuela D'angelo and Matteo Pecchiari and Paolo Baraggia and Marina Saetta and Elisabetta Balestro and Joseph Milic-Emili},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 3},
  pages={949-56}
}
Lung mechanics and morphometry of 10 normal open-chest rabbits (group A), mechanically ventilated (MV) with physiological tidal volumes (8-12 ml/kg), at zero end-expiratory pressure (ZEEP), for 3-4 h, were compared with those of five rabbits (group B) after 3-4 h of MV with a positive end-expiratory pressure (PEEP) of 2.3 cmH(2)O. Relative to initial MV on PEEP, MV on ZEEP caused a progressive increase in quasi-static elastance (+36%) and airway (Rint; +71%) and viscoelastic resistance (+29… CONTINUE READING