Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes.

@article{Little2011LowvolumeHI,
  title={Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes.},
  author={Jonathan Peter Little and Jenna B. Gillen and Michael E. Percival and Adeel Safdar and Mark A. Tarnopolsky and Zubin Punthakee and Mary Elizabeth Jung and Martin J. Gibala},
  journal={Journal of applied physiology},
  year={2011},
  volume={111 6},
  pages={
          1554-60
        }
}
Low-volume high-intensity interval training (HIT) is emerging as a time-efficient exercise strategy for improving health and fitness. This form of exercise has not been tested in type 2 diabetes and thus we examined the effects of low-volume HIT on glucose regulation and skeletal muscle metabolic capacity in patients with type 2 diabetes. Eight patients with type 2 diabetes (63 ± 8 yr, body mass index 32 ± 6 kg/m(2), Hb(A1C) 6.9 ± 0.7%) volunteered to participate in this study. Participants… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes
High‐volume endurance exercise (END) improves glycaemic control in type 2 diabetes (T2D) but many individuals cite ‘lack of time’ as a barrier to regular participation. High‐intensity interval…
High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes
TLDR
It is suggested that HIT may be the preferred training mode for some people with T1D, as HIT improved V˙o2peak and aPWV to a similar extent as MICT.
Can Time Efficient Exercise Improve Cardiometabolic Risk Factors in Type 2 Diabetes? A Pilot Study.
TLDR
It is indicated that substantially lower exercise volumes than recommended in current guidelines can improve aerobic exercise capacity in individuals with type 2 diabetes and could reduce the time-barrier associated with exercise among patients withtype 2 diabetes.
Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial.
TLDR
Compared to MICT, HIIT is not superior at reducing IR, carnosine or musclin or at increasing skeletal muscle mass in adults with MS, and both training types improved IR, muscle mass and body composition.
Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes.
TLDR
Ten days of either HIIT or MICT can improve cardiorespiratory fitness and glucose control and lead to reductions in TLR2 and TLR4 expression and MICT, which involved a longer duration of exercise, may be superior for reducing fasting glucose.
The effect of low-volume high-intensity interval training on cardiometabolic health and psychological responses in overweight/obese middle-aged men
TLDR
It is suggested that low-volume HIIT can elicit a similar improvement of cardiovascular fitness as traditional higher-volume MICT in overweight/obese middle-aged men.
Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function.
TLDR
Increases in mitochondrial content following six HIT sessions may facilitate improvements in respiratory capacity and oxygen extraction, and ultimately are responsible for the improvements in maximal whole body exercise capacity and endurance performance in previously untrained individuals.
Functional high‐intensity training: A HIT to improve insulin sensitivity in type 2 diabetes
  • M. Gibala
  • Medicine
    Experimental physiology
  • 2018
TLDR
The findings demonstrate the feasibility and efficacy of functional high-intensity training in a small group of carefully screened participants under controlled conditions and improve indices of glycaemic control in a time-efficient manner in people with type 2 diabetes.
[High intensity interval training improves glycemic control and aerobic capacity in glucose intolerant patients].
TLDR
HIIT exercise reduces blood glucose after an oral load in glucose intolerant patients, and among adherent participants, twelve weeks of HIIT improved significantly maximal oxygen uptake.
High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients
TLDR
HIIT improves overall glycaemic control, pancreatic function and total fat mass before and after 8 weeks of low volume high intensity interval training (HIIT) on cycle ergometer in T2D patients and matched healthy control individuals.
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