Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.

  title={Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.},
  author={David M. Rodman and Katherine Reese and Julie Wright Harral and Brian Fouty and Songwei Wu and James L. West and Marloes Hoedt-Miller and Yuji Tada and K. Li and Carlyne D Cool and Karen Fagan and Leanne L. Cribbs},
  journal={Circulation research},
  volume={96 8},
While Ca2+ influx is essential for activation of the cell cycle machinery, the processes that regulate Ca2+ influx in this context have not been fully elucidated. Electrophysiological and molecular studies have identified multiple Ca2+ channel genes expressed in mammalian cells. Ca(v)3.x gene family members, encoding low voltage-activated (LVA) or T-type channels, were first identified in the central nervous system and subsequently in non-neuronal tissue. Reports of a potential role for T-type… CONTINUE READING

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