Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels.

@article{Isope2005LowTC,
  title={Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels.},
  author={Philippe Isope and Timothy H. Murphy},
  journal={The Journal of physiology},
  year={2005},
  volume={562 Pt 1},
  pages={257-69}
}
The functional role of low voltage activated (LVA) calcium channels in the cerebellar Purkinje cell dendritic tree is not completely understood. Since the localization of these channels will influence their possible roles in dendritic integration and induction of plasticity, we set out to characterize the LVA calcium current in Purkinje cell dendrites in acute cerebellar slices of young rats. Using a combination of electrophysiological recordings and two-photon laser scanning microscopy, we… CONTINUE READING

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T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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Cold Spring Harbor perspectives in biology • 2012

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