Low-threshold Ca2+ current amplifies distal dendritic signaling in thalamic reticular neurons.

@article{Crandall2010LowthresholdCC,
  title={Low-threshold Ca2+ current amplifies distal dendritic signaling in thalamic reticular neurons.},
  author={Shane R. Crandall and Gubbi Govindaiah and Charles L. Cox},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 46},
  pages={
          15419-29
        }
}
The low-threshold transient calcium current (I(T)) plays a critical role in modulating the firing behavior of thalamic neurons; however, the role of I(T) in the integration of afferent information within the thalamus is virtually unknown. We have used two-photon laser scanning microscopy coupled with whole-cell recordings to examine calcium dynamics in the neurons of the strategically located thalamic reticular nucleus (TRN). We now report that a single somatic burst discharge evokes large… CONTINUE READING
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