Low-template DNA: A single DNA analysis or two replicates?

  title={Low-template DNA: A single DNA analysis or two replicates?},
  author={Simone Gittelson and Carolyn R. Steffen and Michael D. Coble},
  journal={Forensic science international},
This study investigates the following two questions: (1) Should the DNA analyst concentrate the DNA extract into a single amplification or should he/she split it up to do two replicates? (2) Given the electropherogram obtained from a first analysis, is it worthwhile for the DNA analyst to invest in obtaining a second replicate? A decision-theoretic approach addresses these questions by quantitatively expressing the expected net gain (ENG) of each DNA analysis of interest. The results indicate… CONTINUE READING

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