Low temperature techniques in biomedical microanalysis.

  title={Low temperature techniques in biomedical microanalysis.},
  author={Romuald Wr{\'o}blewski and Joanna Wroblewski and Godfried M. Roomans},
  journal={Scanning microscopy},
  volume={1 3},
Many diseases are associated with a change in the distribution of diffusible ions at the cell or tissue level. These diseases can profitably be studied by X-ray microanalysis. This technique for the study of ion distribution requires the use of cryoprepared specimens. Analysis at low or medium resolution can be carried out on thick or semi-thick cryosections, or on frozen-hydrated or freeze-dried embedded bulk samples. Such analyses are particularly useful in the initial stages of an… CONTINUE READING