Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis.

@article{Xu2013LowSI,
  title={Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis.},
  author={Yaqin Xu and Anja Krause and Maria P. Limberis and Tilla S. Worgall and Stefan Worgall},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={48 2},
  pages={
          250-7
        }
}
Dysfunction of the cystic fibrosis transmembrane regulator (CFTR) leads to chronic inflammation and infection of the respiratory tract. The role of CFTR for cells of the pulmonary immune system is only partly understood. The present study analyzes the phenotype and immune stimulatory capacity of lung dendritic cells (DCs) from CFTR knockout (CF) mice. Total numbers of conventional DCs, plasmacytoid DCs, and CD103-positive DCs were lower in CF mice compared with wild-type (WT) control mice, as… CONTINUE READING

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