Low solubility of unconjugated bilirubin in dimethylsulfoxide – water systems: implications for pKa determinations

Abstract

Aqueous pK a values of unconjugated bilirubin are important determinants of its solubility and transport. Published pK a data on an analog, mesobilirubin-XIIIα, studied by 13C-NMR in buffered solutions containing 27 and 64 vol% (C2H3)2SO because of low aqueous solubility of mesobilirubin, were extrapolated to obtain pK a values in water of 4.2 and 4.9… (More)
DOI: 10.1186/1471-2091-3-17

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