Low serum alkaline phosphatase activity in Wilson's disease

@article{Shaver1986LowSA,
  title={Low serum alkaline phosphatase activity in Wilson's disease},
  author={William A. Shaver and Harshika S. Bhatt and Burton Combes},
  journal={Hepatology},
  year={1986},
  volume={6}
}
Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia. A review of other cases of Wilson's disease revealed that 11 of 12 patients presenting with hemolytic anemia had values for serum alkaline phosphatase less than their respective sex‐ and age‐adjusted mean values; in eight, serum alkaline phosphatase activity was less than… 

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References

SHOWING 1-10 OF 36 REFERENCES

SERUM PHOSPHATASE AS AN AID IN THE DIAGNOSIS OF CRETINISM AND JUVENILE HYPOTHYROIDISM

Observations are reported which show that the phosphatase determination is of clinical value as an aid in the diagnosis of hypothyroidism during infancy and childhood.

CYANOCOBALAMIN-DEPENDENT DEPRESSION OF THE SERUM ALKALINE PHOSPHATASE LEVEL IN PATIENTS WITH PERNICIOUS ANEMIA.

A patient suffering from both pernicious anemia and Paget's disease was observed, the serum phosphatase level was normal and increased to abnormal height only after administration of vitamin B12, and one possible explanation was that osteoblastic activity had been depressed by vitamin B 12 deficiency.

Hemolytic anemia in wilson disease: Clinical findings and biochemical mechanisms

In vitro studies of the toxic effects of copper on erythrocytes suggest that the primary toxic effect of copper is mediated through its oxidant actions on membrane phospholipids rather than through its potential inhibitory effects on intracellular enzymes.

Wilson's Disease

This paper records two cases of Wilson's disease in the same family, one severely affected, the other asymptomatic, and the good clinical response of the former to treatment with penicillamine over a period of four years.

Alkaline phosphatase activity in the plasma of children and adolescents.

There was a low trend of increasing activity in both sexes at the beginning of adolescence, which peaked at ages 11 to 12 years in girls and at ages 13 to 14 in boys, and adult values were not reached until six to eight years later.

Wilson's disease (hepatolenticular degeneration) and pregnancy.

There appears to have been significant clinical improvement in the severity of Wilson's disease during, and in the months following, pregnancy.

Fulminant Wilson's disease with haemolysis and renal failure: copper studies and assessment of dialysis regimens.

Peritoneal dialysis alone appears to offer the greatest potential benefit with regard to both eliminating copper and altering the course of this fulminant form of Wilson's disease.

Hemolytic anemia in Wilson's disease.

After this initial episode no further features suggesting hepatic involvement may appear despite neurologic abnormalities of many years' duration, and Wilson's disease is rarely considered at that time.