Low serum alkaline phosphatase activity in Wilson's disease

  title={Low serum alkaline phosphatase activity in Wilson's disease},
  author={William A. Shaver and Harshika S. Bhatt and Burton Combes},
Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia. A review of other cases of Wilson's disease revealed that 11 of 12 patients presenting with hemolytic anemia had values for serum alkaline phosphatase less than their respective sex‐ and age‐adjusted mean values; in eight, serum alkaline phosphatase activity was less than… 

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