Objective:Increasing evidence point to the role of the adipose tissue on the insulin resistance associated with reduced fetal growth. Since adiponectin, exclusively produced by the adipose tissue, exerts an important insulin-sensitizing activity, it appears critical to investigate the effect of being born small for gestational age (SGA) on adiponectin… (More)
Figure 1 Relationship between serum adiponectin levels and insulinsensitivity in the SGA (n¼486) and AGA (n¼573) groups. Insulin-sensitivity was assessed by the fasting insulin-to-glucose ratio. The two study groups were divided in quartiles of serum adiponectin concentrations, I including subjects with the lowest serum adiponectin levels and IV the subjects with the highest levels. The P-values within each group are given after adjustment for current age, BMI, waist-to-hip ratio, gender, oral contraception, smoking and family history of type 2 diabetes.