Low sensitivity of retina to AMPA-induced calcification.

  title={Low sensitivity of retina to AMPA-induced calcification.},
  author={Noem{\'i} Andr{\'e}s and Yolanda Malpesa and Manuel J Rodr{\'i}guez and Nicole Mahy},
  journal={Journal of neuroscience research},
  volume={72 4},
Glutamate is involved in most CNS neurodegenerative diseases. In particular, retinal diseases such as retinal ischemia, retinitis pigmentosa, and diabetic retinopathy are associated with an excessive synaptic concentration of this neurotransmitter. To gain more insight into retinal excitotoxicity, we carried out a dose-response study in adult rats using alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), a glutamate analogue. AMPA intraocular injections (between 0.27 and 10.8 nmol… CONTINUE READING