Low risk of alloimmunization to the D antigen in D− orthotopic liver transplant recipients receiving D+ RBCs perioperatively

@article{Yuan2008LowRO,
  title={Low risk of alloimmunization to the D antigen in D− orthotopic liver transplant recipients receiving D+ RBCs perioperatively},
  author={Shan Yuan and Rebecca Davis and Qun Lu and Dennis Goldfinger and Alyssa Ziman},
  journal={Transfusion},
  year={2008},
  volume={48}
}

Lack of alloimmunization to the D antigen in D‐negative orthotopic liver transplant recipients receiving D‐positive red blood cells perioperatively

TLDR
This study evaluates the prevalence of anti‐D formation in D‐negative OLT patients who received D‐positive RBCs perioperatively, as this will assist in successful patient blood management.

Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis

The transfusion of D‐negative red blood cells (RBCs) to D‐negative patients has been widely adopted to prevent anti‐D alloimmunization, especially in women of childbearing age. Still, transfusion of

Blood banking in solid organ transplantation

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Over 150,000 organ transplants are performed annually worldwide, and transfusion medicine support is crucial for each patient. Liver transplants have posed the greatest challenge for transfusion

Safety assessment of RhD-positive red cell transfusion in RhD-negative liver-transplant recipients: Single-centre report from India

TLDR
It may be safe to use RhD-positive RBCs peri-operatively inRhD-negative LDLT recipients with low risk of alloimmunization with six-month follow up for risk of developing alloantibodies.

The use of third‐party packed red blood cells during ex situ normothermic machine perfusion of organs for transplantation: Underappreciated complexities?

TLDR
It is suggested that national transplant and blood transfusion agencies work together to develop a co‐ordinated approach within each country, especially important given the possibility of organ re‐allocation between centers after ex situ NMP, and the ongoing development of organ perfusion hubs.

Risk of RBC alloimmunization in multiple myeloma patients treated by Daratumumab

TLDR
The objective of this study was to evaluate the risk of RBC alloimmunization in MM patients treated with DARA.

Prospective evaluation of immune haemolysis in liver transplantation

TLDR
Evaluation of the prevalence and risk factors for immune haemolysis in liver transplant patients in LT found autoantibodies and alloantibody levels were higher than expected.

Red blood cell alloantibodies are associated with increased alloimmunization against human leukocyte antigens

Alloantibodies recognizing human leukocyte antigens (HLA) can cause immune‐mediated refractoriness to platelet transfusion. An association between HLA alloimmunization and red blood cell (RBC)

Predisposing factors for anti‐D immune response in D− patients with chronic liver disease transfused with D+ platelet concentrates

TLDR
The rate of anti‐D alloimmunization in RhD‐negative (D−) patients with chronic liver disease transfused with D+ platelet concentrates (PCs) and the factors involved, at a liver transplant (LT) center are investigated.

Rhesus Alloimunization Occurs After Rh Incompatible Liver Transplantation in Children.

TLDR
R (Rh) mismatch in liver transplantation is not taken into consideration for organ matching in centers across the world and there is no consensus guidelines regarding the need to administer RhD immunoglobulin (RhDIg) to such patients to prevent these potential complications.

References

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Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.

Abstract The transfusion records of 102 Rh-negative patients treated with platelet transfusions from Rh-positive donors showed a 7.8 per cent rate of sensitization to the Rh0 (D) antigen. All but o...

Detection of anti‐D in D– recipients transfused with D+ red blood cells

TLDR
A study of the alloimmunization rate of primarily nononcology D– recipients transfused with D+ RBCs was undertaken and found that the D antigen is highly immunogenic, requiring only a small quantity of transfused red blood cells to cause alloIMmunization in D– immunocompetent recipients.

Lack of alloimmunization to D antigen in D‐negative immunosuppressed liver transplant recipients

TLDR
An adequate supply of Rh‐negative blood for Rh‐ negative patients is not always available and Orthotopic liver transplantation (OLT) sometimes requires large amounts of blood.

Low rate of Rhesus immunization from Rh-incompatible blood transfusions during liver and heart transplant surgery.

TLDR
A low rate of Rhesus immunization in association with cyclosporine immunosuppression allows greater flexibility in meeting the transfusion needs of Rh- liver and heart transplant patients.