Low respiratory rate plus minimally invasive extracorporeal Co2 removal decreases systemic and pulmonary inflammatory mediators in experimental Acute Respiratory Distress Syndrome.

@article{Grasso2014LowRR,
  title={Low respiratory rate plus minimally invasive extracorporeal Co2 removal decreases systemic and pulmonary inflammatory mediators in experimental Acute Respiratory Distress Syndrome.},
  author={Salvatore Grasso and Tania Stripoli and Palma Mazzone and Marco Pezzuto and Luca Lacitignola and Paola Centonze and Alessandro Guarracino and Cosimo Esposito and Peter Herrmann and Michael Quintel and Paolo Trerotoli and Francesco Bruno and Antonio Crovace and Francesco Staffieri},
  journal={Critical care medicine},
  year={2014},
  volume={42 6},
  pages={e451-60}
}
OBJECTIVE The Acute Respiratory Distress Syndrome Network protocol recommends limiting tidal volume and plateau pressure; it also recommends increasing respiratory rate to prevent hypercapnia. We tested a strategy that combines the low tidal volume with lower respiratory rates and minimally invasive CO2 removal. SUBJECTS Ten lung-damaged pigs (instilled hydrochloride). INTERVENTIONS Two conditions randomly applied in a crossover fashion: the Acute Respiratory Distress Syndrome Network… CONTINUE READING
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