Low renin-aldosterone in "prehypertensive" young adults.

  title={Low renin-aldosterone in "prehypertensive" young adults.},
  author={Theodore Kotchen and Gordon Guthrie and Carol M. Cottrill and Harlley E Mckean and Jane Morley Kotchen},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={54 4},
PRA is suppressed in approximately 25% of patients with essential hypertension. To determine if renin suppression precedes the onset of hypertension, PRA and plasma aldosterone were measured before and after treadmill exercise in 129 young adults with relatively high, intermediate, or relatively low blood pressures sustained over 5 yr. PRA and aldosterone responses to exercise were lower (P less than 0.01) in the high blood pressure group. In contrast, plasma renin substrate was lower (P less… CONTINUE READING