Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo.

@article{Gullbrand2015LowRL,
  title={Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo.},
  author={S. Gullbrand and J. Peterson and R. Mastropolo and T. T. Roberts and J. P. Lawrence and J. Glennon and D. dirisio and E. Ledet},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2015},
  volume={15 5},
  pages={
          1028-33
        }
}
  • S. Gullbrand, J. Peterson, +5 authors E. Ledet
  • Published 2015
  • Medicine, Materials Science
  • The spine journal : official journal of the North American Spine Society
  • BACKGROUND CONTEXT The intervertebral disc primarily relies on trans-endplate diffusion for the uptake of nutrients and the clearance of byproducts. In degenerative discs, diffusion is often diminished by endplate sclerosis and reduced proteoglycan content. Mechanical loading-induced convection has the potential to augment diffusion and enhance net transport into the disc. The ability of convection to augment disc transport is controversial and has not been demonstrated in vivo. PURPOSE To… CONTINUE READING
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