Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo.

@article{Gullbrand2015LowRL,
  title={Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo.},
  author={Sarah E. Gullbrand and Joshua M. Peterson and Rosemarie Mastropolo and Timothy T Roberts and James P. Lawrence and Joseph C Glennon and Darryl J DiRisio and Eric H. Ledet},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2015},
  volume={15 5},
  pages={1028-33}
}
BACKGROUND CONTEXT The intervertebral disc primarily relies on trans-endplate diffusion for the uptake of nutrients and the clearance of byproducts. In degenerative discs, diffusion is often diminished by endplate sclerosis and reduced proteoglycan content. Mechanical loading-induced convection has the potential to augment diffusion and enhance net transport into the disc. The ability of convection to augment disc transport is controversial and has not been demonstrated in vivo. PURPOSE To… CONTINUE READING
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Apparent diffusion coefficient of intervertebral discs related to 1033 S.E

  • J Antoniou, CN Demers, G Beaudoin, T Goswami, F Mwale, M Aebi
  • Gullbrand et al. / The Spine Journal
  • 2015
1 Excerpt

Effect of endplate calcification andmechanical deformation on the distribution of glucose in intervertebral disc : a 3 D finite element study

  • HuangC JacksonA
  • Comput Methods Biomech Biomed Engin
  • 2011

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