Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes.

@article{Vehmanen1997LowPO,
  title={Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes.},
  author={Paula Vehmanen and Lori S. Friedman and Hannaleena Eerola and Matthew McClure and Brian Ward and Laura Sarantaus and Tommi Kainu and Kirsi Syrj{\"a}koski and Seppo O. Pyrh{\"o}nen and Olli Kallioniemi and Timo Muhonen and Modesto Luce and Thomas S. Frank and Heli Nevanlinna},
  journal={Human molecular genetics},
  year={1997},
  volume={6 13},
  pages={
          2309-15
        }
}
One hundred breast and breast-ovarian cancer families identified at the Helsinki University Central Hospital in southern Finland and previously screened for mutations in the BRCA2 gene were now analyzed for mutations in the BRCA1 gene. The coding region and splice boundaries of BRCA1 were analyzed by protein truncation test (PTT) and heteroduplex analysis (HA)/SSCP in all 100 families, and 70 were also screened by direct sequencing. Contrary to expectations based on Finnish population history… CONTINUE READING

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