Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.

@article{Exel2002LowPC,
  title={Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study.},
  author={Eric van Exel and Jacobijn Gussekloo and Anton J. M. de Craen and Marijke Fr{\"o}lich and Annetje Bootsma-van der Wiel and Rudi G. J. Westendorp},
  journal={Diabetes},
  year={2002},
  volume={51 4},
  pages={1088-92}
}
It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and anti-inflammatory cytokines that are under genetic control. We therefore hypothesized that a low production capacity of interleukin-10 (IL-10), a centrally operating cytokine with strong anti-inflammatory properties, associates with the metabolic syndrome and type 2 diabetes in old age. In the current study… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…