Low prevalence of thyrotropin receptor mutations in a large series of subjects with sporadic and familial nonautoimmune subclinical hypothyroidism.

@article{Tonacchera2004LowPO,
  title={Low prevalence of thyrotropin receptor mutations in a large series of subjects with sporadic and familial nonautoimmune subclinical hypothyroidism.},
  author={Massimo Tonacchera and Anna Perri and Giuseppina de Marco and Patrizia Agretti and Maria Elena Banco and Caterina di Cosmo and Lucia Grasso and Paolo Vitti and Luca Chiovato and Aldo Pinchera},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 11},
  pages={5787-93}
}
Subclinical hypothyroidism of chronic autoimmune thyroiditis must be distinguished from the rare condition of thyroid resistance to TSH in which variable degrees of congenital insensitivity of the thyroid to a biologically active TSH molecule are present. We studied 42 subjects with slight to moderate elevations of circulating TSH and normal free thyroid hormone levels in whom the diagnosis of autoimmune thyroid disease had been excluded using the best of the currently available laboratory and… CONTINUE READING
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