Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.

@article{Syed2004LowPO,
  title={Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.},
  author={Akheel A Syed and J. E. Irving and Christopher P F Redfern and Andrew G Hall and Peter Nigel Unwin and Martin White and Raj S Bhopal and K George Mm Alberti and Jolanta U. Weaver},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 1},
  pages={
          232-5
        }
}
Similarities between clinical states of glucocorticoid excess and obesity have raised suspicion of a link between the two conditions. An Asn363Ser (N363S) polymorphism in exon 2 of the glucocorticoid receptor has been associated with glucocorticoid sensitivity and excess adiposity in people of European origin. Compared with Europid populations, South Asians have a higher prevalence of cardiovascular risk factors, including type 2 diabetes and central obesity. The aim of this study was to… CONTINUE READING
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