Low prevalence of the JAK2V617F in patients with ischemic stroke or cerebral venous thrombosis.


Quebec platelet disorder (QPD) is an autosomal dominant bleeding disorder associated with increased risks for bleeding and the expression and storage of urokinase plasminogen activator (u-PA) in platelets, despite normal u-PA in plasma (reviewed in [1]). In the recent article on QPD published in this journal [1], QPD was proposed to result from defective u-PA regulation by megakaryocytes. However, the levels of u-PA in other QPD cells and urine have not been reported. Individuals with QPD are at increased risk of experiencing bleeding following hemostatic challenges, and approximately 50% experience episodic, spontaneous hematuria, which is associated with higher levels of platelet u-PA [2]. As urine normally contains significant amounts of u-PA (40–80mg/ml) [3], we investigated whether individuals with QPD have an increased urinary u-PA as a potential contributor to their urinary tract bleeding.

DOI: 10.1097/MBC.0b013e328304e0a9

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@article{Xavier2008LowPO, title={Low prevalence of the JAK2V617F in patients with ischemic stroke or cerebral venous thrombosis.}, author={Sandra Guerra Xavier and Telma Gadelha and Rony Schaffel and Luciana Britto and Glic{\'i}nia Pimenta and Daniel Dias Ribeiro and Adriano de Paula Sabino and Virg{\'i}nia Mr Pires and Ilana Zalcberg Renault and Nelson Spector}, journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis}, year={2008}, volume={19 5}, pages={468-9} }