Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging

@inproceedings{Semba2019LowPL,
  title={Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging},
  author={Richard David Semba and Pingbo Zhang and Fatemeh Adelnia and Kai Sun and Marta Gonzalez‐Freire and Norman Salem and Nicholas Brennan and Richard G. Spencer and Kenneth W. Fishbein and Mohammed Abdul Khadeer and Michelle Shardell and Ruin Moaddel and Luigi Ferrucci},
  booktitle={Aging cell},
  year={2019}
}
The decrease in skeletal muscle mitochondrial oxidative capacity with age adversely affects muscle strength and physical performance. Factors that are associated with this decrease have not been well characterized. Low plasma lysophosphatidylcholines (LPC), a major class of systemic bioactive lipids, are predictive of aging phenotypes such as cognitive impairment and decline of gait speed in older adults. Therefore, we tested the hypothesis that low plasma LPC are associated with impaired… CONTINUE READING
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