Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses.

Abstract

The kinetics of caspofungin (CAS) in cerebrospinal fluid (CSF) following intravenous (i.v.) administration has been studied exclusively in animal models. Human data are missing so far. In this study, 13 CSF samples were obtained at different time points following i.v. infusion of CAS in ten paediatric haemato-/oncological patients (age range 1.0-14.2 years… (More)
DOI: 10.1016/j.ijantimicag.2017.02.024

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