Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

@inproceedings{Lambrot2013LowPD,
  title={Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes},
  author={Romain Lambrot and Cao Xu and Shawna Saint-Phar and G. Chountalos and Tamara R. Cohen and Mireille Paquet and Matthew J. Suderman and M. Hallett and Sarah Kimmins},
  booktitle={Nature communications},
  year={2013}
}
Epidemiological studies suggest that a father's diet can influence offspring health. A proposed mechanism for paternal transmission of environmental information is via the sperm epigenome. The epigenome includes heritable information such as DNA methylation. We hypothesize that the dietary supply of methyl donors will alter epigenetic reprogramming in sperm. Here we feed male mice either a folate-deficient or folate-sufficient diet throughout life. Paternal folate deficiency is associated with… CONTINUE READING
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