Low pH facilitates capsaicin responses in isolated sensory neurons of the rat

@article{Kress1996LowPF,
  title={Low pH facilitates capsaicin responses in isolated sensory neurons of the rat},
  author={Michaela Kress and S. Fetzer and Peter W. Reeh and Ladislav Vyklick{\'y}},
  journal={Neuroscience Letters},
  year={1996},
  volume={211},
  pages={5-8}
}
The effects of capsaicin (CAPS; 30 nM, 300 nM, 3 microM) and acidic solutions (pH 6.6, 6.1, 5.6, 5.1) were studied in dorsal root ganglion (DRG) neurons from adult rats in short term culture using the whole cell patch-clamp technique and a system for fast drug application. At -60 mV holding potential, both CAPS 30 nM and 300 nM for 10 s did not induce a significant membrane current in pH 7.3. The first response to 3 microM CAPS at pH 7.3 yielded an inward current of 898 +/- 517 pA and with pH 6… CONTINUE READING

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