Low p27Kip1 expression is an independent prognostic factor in gallbladder carcinoma.

@article{Filipits2003LowPE,
  title={Low p27Kip1 expression is an independent prognostic factor in gallbladder carcinoma.},
  author={Martin Filipits and Harald Puhalla and Friedrich Wrba},
  journal={Anticancer research},
  year={2003},
  volume={23 1B},
  pages={675-9}
}
BACKGROUND The cyclin-dependent kinase inhibitor p27Kip1 is an important regulator of the cell cycle and low expression of p27Kip1 is associated with poor prognosis in a variety of malignant diseases. The objective of the current study was to determine the prognostic value of this protein in patients with gallbladder carcinoma. MATERIALS AND METHODS We studied p27Kip1 expression in 55 unselected patients with gallbladder carcinoma by means of immunohistochemistry and evaluated its impact on… CONTINUE READING
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