Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells.

@article{DIppolito2006LowOT,
  title={Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells.},
  author={Gianluca D'Ippolito and Sylma Diabira and Guy A. Howard and Bernard A. Roos and Paul C. Schiller},
  journal={Bone},
  year={2006},
  volume={39 3},
  pages={513-22}
}
We recently reported the isolation of a unique subpopulation of human stromal cells from bone marrow (BM) termed marrow-isolated adult multilineage inducible (MIAMI) cells, capable of differentiating in vitro into mature-like cells from all three germ layers. The oxygen tension (pO2) in BM ranges from 1 to 7%, which prompted us to examine the role of pO2 in regulating the capacity of MIAMI cells both to self-renew and maintain their pluripotentiality (stemness) or to progress toward… CONTINUE READING

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