Low oxygen tension and macromolecular crowding accelerate extracellular matrix deposition in human corneal fibroblast culture.

Abstract

Development of implantable devices based on the principles of in vitro organogenesis has been hindered due to the prolonged time required to develop an implantable device. Herein we assessed the influence of serum concentration (0.5% and 10%), oxygen tension (0.5%, 2% and 20%) and macromolecular crowding (75 μg/ml carrageenan) in extracellular matrix… (More)
DOI: 10.1002/term.2283

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