Low oxygen concentrations inhibit trophoblast cell invasion from early gestation placental explants via alterations in levels of the urokinase plasminogen activator system.

@article{Lash2006LowOC,
  title={Low oxygen concentrations inhibit trophoblast cell invasion from early gestation placental explants via alterations in levels of the urokinase plasminogen activator system.},
  author={Gendie E. Lash and Harry A Otun and Barbara A. Innes and Judith N. Bulmer and Roger F. Searle and Stephen C. Robson},
  journal={Biology of reproduction},
  year={2006},
  volume={74 2},
  pages={403-9}
}
Extravillous trophoblast cell (EVT) invasion in early pregnancy occurs in a relatively low-oxygen environment. The role of oxygen in regulation of EVT invasion remains controversial. We hypothesized that 1) culture in 3% oxygen inhibits EVT invasion compared with culture at 8% or 20% oxygen and 2) inhibition of invasion is due to alterations in levels of components of the urokinase plasminogen activator (PLAU, uPA) system rather than through increased apoptosis and/or decreased proliferation… CONTINUE READING

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