Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein

@article{Dimartino2006LowOA,
  title={Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein},
  author={Jorge F Dimartino and Norman J. Lacayo and M{\'a}ria V{\'a}radi and Lei Li and C Saraiya and Yaddanapudi Ravindranath and R Yu and Branimir Sikic and Susana C. Raimondi and Gary V H Dahl},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={426-432}
}
Secreted protein, acidic and rich in cysteine (SPARC), is a matricellular glycoprotein with growth-inhibitory and antiangiogenic functions. Although SPARC has been implicated as a tumor suppressor in humans, its function in normal or malignant hematopoiesis has not previously been studied. We found that the leukemic cells of AML patients with MLL gene rearrangements express low to undetectable amounts of SPARC whereas normal hematopoietic progenitors and most AML patients express this gene… CONTINUE READING
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