Low nigrostriatal reserve for motor parkinsonism in nonhuman primates.

  title={Low nigrostriatal reserve for motor parkinsonism in nonhuman primates.},
  author={Samer D Tabbal and Linlin Tian and Morvarid K Karimi and Christopher A Brown and Susan K. Loftin and Joel S. Perlmutter},
  journal={Experimental neurology},
  volume={237 2},
OBJECTIVE Nigrostriatal reserve refers to the threshold of neuronal injury to dopaminergic cell bodies and their terminal fields required to produce parkinsonian motor deficits. Inferential studies have estimated striatal dopamine reserve to be at least 70%. Knowledge of this threshold is critical for planning interventions to prevent symptom onset or reverse nigrostriatal injury sufficient to restore function in people with Parkinson disease. In this study, we determine the nigrostriatal… CONTINUE READING
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