Low myo-inositol and high glutamine levels in the brain are associated with neuropsychological deterioration following induced hyperammonemia

@inproceedings{Shawcross2004LowMA,
  title={Low myo-inositol and high glutamine levels in the brain are associated with neuropsychological deterioration following induced hyperammonemia},
  author={D L Shawcross and Sherzad Balata and Steven W.M. Olde Damink and Peter Hayes and Joanna M. Wardlaw and Ian Marshall and Nicolaas E. P. Deutz and Richard A. Williams and Rajiv Jalan},
  year={2004}
}
Background: The neuropsychological effect of hyperammonemia is variable. This study tests the hypothesis that the effect of ammonia on the neuropsychological function in patients with cirrhosis is determined by the ability of the brain to ‘buffer’ ammonia-induced increase in glutamine within the astrocyte by losing osmolytes like myo-inositol (mI) and not by the magnitude of the ‘induced hyperammonemia’. Methods: Fourteen cirrhotic patients with no evidence of overt HE were given a 75 gram… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

The influence of age on trail making test performance

  • A. Davies
  • J Clin Psychol
  • 1968
Highly Influential
4 Excerpts

Pathophysiology of hepatic encephalopathy: the ammonia hypothesis revisited

  • R. Butterworth
  • Bengtsson F JBATeale, editor. Hepatic. Boca Raton…
  • 1993
Highly Influential
3 Excerpts

The kidney plays a major role in the hyperammonemia seen after a simulated or actual upper gastrointestinal bleeding in patients with cirhosis

  • S Olde Damink, R Jalan, N Deutz, D Redhead, C Dejong, P Hynd
  • Hepatology
  • 2003
2 Excerpts

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