Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.

@article{Suzuki2002LowMI,
  title={Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.},
  author={Koichi Suzuki and Tomoko Dai and Ikuko Suzuki and Yuichi Dai and Kentaro Yamashita and Manuel Perucho},
  journal={Cancer research},
  year={2002},
  volume={62 7},
  pages={1961-5}
}
Frameshifts in short mononucleotide tracts (SMT) in genes, such as TGFbetaRII and BAX, are common in gastrointestinal tumors of the microsatellite mutator phenotype (MMP). The significance of less common mutations has been recently challenged because frequencies as high as 50% were reported in some noncoding SMTs in MMP colon cancer cell lines (L. Zhang, et al., Cancer Res., 61: 3801-3805, 2001). We did not confirm these findings after examining >50 MMP gastrointestinal cancers for mutations in… CONTINUE READING

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