Low-molecular-weight thiol-dependent antioxidant and antinitrosative defences in Salmonella pathogenesis.


We found herein that the intracytoplasmic pool of the low-molecular-weight (LMW) thiol glutathione (GSH) is readily oxidized in Salmonella exposed to nitric oxide (NO). The hypersusceptibility of gshA and gshB mutants lacking γ-glutamylcysteine and glutathione synthetases to NO and S-nitrosoglutathione indicates that GSH antagonizes the bacteriostatic… (More)
DOI: 10.1111/mmi.12119



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