Low molecular weight silk fibroin increases alkaline phosphatase and type I collagen expression in MG63 cells.

@article{Kim2010LowMW,
  title={Low molecular weight silk fibroin increases alkaline phosphatase and type I collagen expression in MG63 cells.},
  author={Jwa-Young Kim and Je-Yong Choi and Jae-Hwan Jeong and Eun-Sik Jang and An-Sook Kim and Seong Gon Kim and Hae Yong Kweon and You-Young Jo and Joo-hong Yeo},
  journal={BMB reports},
  year={2010},
  volume={43 1},
  pages={
          52-6
        }
}
Silk fibroin, produced by the silkworm Bombyx mori, has been widely studied as a scaffold in tissue engineering. Although it has been shown to be slowly biodegradable, cellular responses to degraded silk fibroin fragments are largely unknown. In this study, silk fibroin was added to MG-63 cell cultures, and changes in gene expression in the MG-63 cells were screened by DNA microarray analysis. Genes showing a significant (2-fold) change were selected and their expression changes confirmed by… CONTINUE READING
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