Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.

@article{Xiao2012LowMW,
  title={Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.},
  author={Jisheng Xiao and Xiaopin Duan and Qi Yin and Lingli Chen and Zhiwen Zhang and Yaping Li},
  journal={Bioconjugate chemistry},
  year={2012},
  volume={23 2},
  pages={
          222-31
        }
}
The development of safe and efficient gene delivery systems is still a challenge for successful gene therapy. In this work, low molecular weight polyethylenimine (PEI 2K) was modified by Tween 85, which bears three oleate chains. Tween 85 modified PEI 2K (TP) could condense DNA efficiently, and TP/DNA complexes (TPCs) showed high resistance to salt-induced aggregation and enzymatic degradation. In addition, TP did not show the obvious cytotoxicity. The introduction of Tween 85 led to a… CONTINUE READING
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