Low molecular weight peptidic fraction in the chromatin from normal and cancer cells: Control of transcription

@article{Gianfranceschi1980LowMW,
  title={Low molecular weight peptidic fraction in the chromatin from normal and cancer cells: Control of transcription},
  author={Gian Luigi Gianfranceschi and Marian Hillar and Jarvis T. Chan and Domenico Amici},
  journal={Molecular Biology Reports},
  year={1980},
  volume={6},
  pages={95-103}
}
DNA isolated from cell nuclei by intensive deproteinization with chloroform/isoamyl alcohol and phenol extractions contains a low molecular weight peptidic fraction in a quantity of about 20 μg/mg DNA. These peptides were characterized by chromatography on CM-Sephadex, Sephadex G-25, high performance liquid chromatography on μBondapak C18 and amino acid composition. The peptides control transcription in a reconstituted cell-free system with prokaryotic and eukaryotic RNA polymerase and… CONTINUE READING
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