Low-molecular-weight oxidants involved in disulfide bond formation.

@article{Ruddock2012LowmolecularweightOI,
  title={Low-molecular-weight oxidants involved in disulfide bond formation.},
  author={Lloyd W Ruddock},
  journal={Antioxidants & redox signaling},
  year={2012},
  volume={16 10},
  pages={1129-38}
}
SIGNIFICANCE The biogenesis of most secreted and outer membrane proteins involves the formation of structure stabilizing disulfide bonds. Hence knowledge of the mechanisms for their formation is critical for understanding a myriad of cellular processes and associated disease states. RECENT ADVANCES Until recently it was thought that members of the Ero1 sulfhydryl oxidase family were responsible for catalyzing the majority of disulfide bond formation in the endoplasmic reticulum. However… CONTINUE READING