Low molecular weight inhibitors of Myc–Max interaction and function

@article{Yin2003LowMW,
  title={Low molecular weight inhibitors of Myc–Max interaction and function},
  author={Xiaoying Yin and Christine Giap and John S. Lazo and Edward V. Prochownik},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6151-6159}
}
c-Myc is helix–loop–helix–leucine zipper (HLH–ZIP) oncoprotein that is frequently deregulated in human cancers. In order to bind DNA, regulate target gene expression, and function in a biological context, c-Myc must dimerize with another HLH–ZIP protein, Max. A large number of c-Myc target genes have been identified, and many of the encoded proteins are transforming. Such functional redundancy, however, complicates therapeutic strategies aimed at inhibiting any single target gene product. Given… 
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This review summarizes the current knowledge on small organic molecules that inhibit c-Myc by modulating protein-protein interactions relevant for the biological function of this important oncoprotein.
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