Low molecular weight inhibitors of Myc–Max interaction and function

@article{Yin2003LowMW,
  title={Low molecular weight inhibitors of Myc–Max interaction and function},
  author={X. Yin and Christine Giap and J. Lazo and E. Prochownik},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6151-6159}
}
c-Myc is helix–loop–helix–leucine zipper (HLH–ZIP) oncoprotein that is frequently deregulated in human cancers. In order to bind DNA, regulate target gene expression, and function in a biological context, c-Myc must dimerize with another HLH–ZIP protein, Max. A large number of c-Myc target genes have been identified, and many of the encoded proteins are transforming. Such functional redundancy, however, complicates therapeutic strategies aimed at inhibiting any single target gene product. Given… Expand
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