Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.

@article{Sokolowska2014LowMW,
  title={Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.},
  author={Milena Sokolowska and L Chen and Michael Eberlein and Asuncion Martinez-Anton and Yueqin Liu and Sara Alsaaty and Hai-Yan Qi and Carolea Logun and Maureen R. Horton and James H. Shelhamer},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 7},
  pages={4470-88}
}
Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During inflammation, there is an increased breakdown of HA, resulting in the accumulation of low molecular weight (LMW) HA and activation of monocytes and macrophages. Eicosanoids, derived from the cytosolic phospholipase A2 group IVA (cPLA2α) activation, are potent lipid mediators also attributed to acute and chronic inflammation. The aim of this study was to determine the effect of LMW HA on cPLA2α activation… CONTINUE READING