Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans.

@article{Frydman1996LowmolecularweightHA,
  title={Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans.},
  author={A. Frydman},
  journal={Haemostasis},
  year={1996},
  volume={26 Suppl 2},
  pages={
          24-38
        }
}
Low-molecular-weight heparins (LMWHs) comprise a group in the class of antithrombotic medications, a class headed by unfractionated heparin (UFH). The LMWHs, with mean molecular weights of 4.0-6.0 kD, differ in their individual manufacturing processes, the distribution of their fragment molecular weights, their in vitro potency (anti-Xa, antithrombin and anticoagulant activities) and, consequently, in their biodynamic patterns, recommended dose regimen, and efficacy/safety ratio. Their drug… CONTINUE READING

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