Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs warfarin in hip arthroplasty patients: a double-blind, randomized comparison. The North American Fragmin Trial Investigators.

@article{Hull2000LowmolecularweightHP,
  title={Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs warfarin in hip arthroplasty patients: a double-blind, randomized comparison. The North American Fragmin Trial Investigators.},
  author={Russell Douglas Hull and Graham Frederick Pineo and Chris Francis and David Bergqvist and Carin Fellenius and Kjell Soderberg and A Holmqvist and Michael J. Mant and Richard Dear and Barry Baylis and Allan K. Mah and Rollin Brant},
  journal={Archives of internal medicine},
  year={2000},
  volume={160 14},
  pages={2199-207}
}
BACKGROUND Based on the current understanding that venous thrombosis starts perioperatively, administration of just-in-time low-molecular-weight heparin immediately before or in close proximity after hip arthroplasty may be more effective than usual clinical practice. METHODS We performed a randomized, double-blind trial comparing subcutaneous dalteparin sodium given once daily immediately before or early after surgery with the use of postoperative warfarin sodium in 1472 patients undergoing… CONTINUE READING