Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation.

@article{Johansson2006LowMW,
  title={Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation.},
  author={Helena Johansson and Masafumi Goto and Denis Dufrane and Agneta Siegbahn and Graciela Elgue and Pierre Rene Gianello and Olle Korsgren and Bo N Nilsson},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2006},
  volume={6 2},
  pages={305-12}
}
The instant blood-mediated inflammatory reaction (IBMIR) is triggered in clinical islet transplantation when human pancreatic islets come in contact with blood and may explain the initial tissue loss associated with this procedure. Low molecular weight dextran sulfate (LMW-DS; MM 5000), today available for clinical use, inhibits both complement and coagulation activation. In a tubing loop model, LMW-DS at concentrations ranging from 0.01 to 1 g/L showed a dose-dependent inhibition of IBMIR with… CONTINUE READING

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