Low molecular weight antioxidants and their role in skin ageing

  title={Low molecular weight antioxidants and their role in skin ageing},
  author={Maurizio Podda and Marcella Grundmann-Kollmann},
  journal={Clinical and Experimental Dermatology},
There is increasing evidence that reactive oxygen species play a pivotal role in the process of ageing. The skin, as the outermost barrier of the body, is exposed to various exogenous sources of oxidative stress, in particular UV‐irradiation. These are believed to be responsible for the extrinsic type of skin ageing, termed photo‐ageing. It therefore seems reasonable to try to increase levels of protective low molecular weight antioxidants through a diet rich in fruits and vegetables or by… 
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The main evidence of the benefits brought by the topical application of antioxidants in the skin is summarized, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests.
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Protective effects of topical antioxidants in humans.
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    Archives of biochemistry and biophysics
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Using one-electron reduction potentials, the predicted pecking order is in agreement with experimentally observed free radical electron (hydrogen atom) transfer reactions and suggests that vitamin E, the primary lipid soluble small molecules antioxidant, and vitamin C, the terminal water soluble small molecule antioxidant, cooperate to protect lipids and lipid structures against peroxidation.
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