Low modularity of aminoacyl-tRNA substrates in polymerization by the ribosome

@inproceedings{Forster2009LowMO,
  title={Low modularity of aminoacyl-tRNA substrates in polymerization by the ribosome},
  author={Anthony C Forster},
  booktitle={Nucleic acids research},
  year={2009}
}
Aminoacyl-transfer RNAs contain four standardized units: amino acids, an invariant 3'-terminal CCA, trinucleotide anticodons and tRNA bodies. The degree of interchangeability of the three variable modules is poorly understood, despite its role in evolution and the engineering of translation to incorporate unnatural amino acids. Here, a purified translation… CONTINUE READING